Peiminine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Peiminine 是博来霉素诱导的肺损伤大鼠模型中肺部炎症和肺纤维化的有效抑制剂。

Peiminine is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.

Cell Cytotoxicity Assay Cell Line:HepG2, Hela, SW480, MCF-7 Concentration:2 μg/mL, 4 μg/mL, 6 μg/mL, 8 μg/mL, 10 μg/mL, 12μg/mL, and 14 μg/mL Incubation Time:24 h, 48 h, 72 h Result:Exhibited a significant inhibition on the survival of HepG2, Hela, SW480 and MCF-7 cells with the IC50 values were 4.58, 4.89, 5.07 and 5.12 μg/mL at 24 h, respectively.Apoptosis Analysis Cell Line:HepG2 Concentration:2 μg/mL, 4 μg/mL, 6 μg/mL, 8 μg/mL Incubation Time:24 h Result:Dissociated chromosome to produce DNA fragments dose-dependently.Cell Cycle Analysis Cell Line:HepG2 Concentration:2 μg/mL, 4 μg/mL, 6 μg/mL Incubation Time:24 h Result:Decreased the percentage of G1 phases from 65.15% ± 0.78 to 49.55% ± 0.17 with the increase of concentrations. Increased the percentage of G2/M phases from 17.32% ± 0.20 to 39.99% ± 0.47 with the increase of concentrations.Western Blot Analysis Cell Line:HepG2 Concentration:2 μg/mL, 4 μg/mL, 6 μg/mL Incubation Time:24 h Result:Reduced the expression of procaspase-3, PARP1, procaspases-8 and -9, and Bcl-2 at 2-6 μg/mL.

Animal Model:ulcerative colitis model Dosage:3mg/kg Administration:Intraperitoneal injection (i.p.)Result:Reduced inflammation, mucosal ulcers, involvement of digestive system layers, and infltration of inflammatory cells.Reduced the levels of MPO and NO generated in the rectal tissue.Reduced cell proliferation in spleen cell.Decreased the production of f IL-1β, IL-6, and TNF-α cytokines.Reduced expression levels of genes IL-1β, IL-6, TNF-α, iNOS, and COX2.Animal Model:Ovariectomized (OVX) rat model Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Alleviated the bone loss caused by surgical castration.Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.Animal Model:Allergic dermatitis model Dosage:1 mg/kg, 5 mg/kg Administration:were applied to the dorsal skin Result:Alleviated the bone loss caused by surgical castration.Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.

Verticinone | Raddeanine

Angiogenesis

EGFR

Others

Inflammation/Immunology

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18059-10-4

429.64

C27H43NO3

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 232.75 mM

CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O

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(-20℃)

With Ice Pack

≥ 2 years