QX77

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

QX77 是一种分子伴侣介导的自噬 (CMA) 激活剂。

QX77 is a chaperone-mediated autophagy (CMA) activator.

QX77 (48 hours) upregulates Rab11 expression levels in Ctns-/-?MEFs.In Ctns-/- MEFs, QX77 recovers the down-regulated LAMP2A expression, and the Rab11-positive carrier vesicles recover the high-motility trafficking phenotype observe in wild-type cells.Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane.QX77 significantly increases the re-localization of LAMP2A at LAMP1-positive lysosomes in cystinotic cell, it corrects the localization of LAMP2A at the lysosomal membrane in cystinotic cells.QX77 protects cystinotic cells from the increased susceptibility totert-butyl-hydroperoxide-induced oxidative stress and reconstitutes the resistant levels observed in wild-type cells. The effect of QX77 on cystinotic cell survival is dependent on LAMP2A expression.QX77 (10 μM;0, 3 or 6 days) activates CMA and increases LAMP2A expression inD3 and E14 ES cell, it downregulates pluripotency factors and AP reactivity and partially lost the characteristic ES cell morphology.Western Blot Analysis Cell Line:ES D3 cell line; E14TG2a (E14) cell line Concentration:10 μM Incubation Time:3 or 6 days Result:Increased LAMP2A expression and decreased SOX2 and Oct4 protein expression.

——

——

Angiogenesis

HIF/HIF Prolyl-hydroxylase

Others

Cancer

——

1798331-92-6

300.74

C16H13ClN2O2

>98% (HPLC)

DMSO : ≥ 64 mg/mL; 212.81 mM

CC(=O)Nc1ccc(cc1)C2=Nc3ccc(Cl)cc3OC2

——

(-20℃)

With Ice Pack

≥ 2 years