HIF-1α-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HIF-1α-IN-2 是一种有效的 HIF-1α 抑制剂，具有抗癌作用，在 MDA-MB-231 和 MiaPaCa-2 细胞 IC50 中分别为 28 nM 和 15 nM。HIF-1α-IN-2 通过阻断转录和蛋白质翻译抑制来 HIF-1α 的表达。

HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2?suppresses HIF-1α expression by blocking transcription and?protein translation.

Cell Viability Assay Cell Line:MDA-MB-231 cells, MiaPaCa-2 cells Concentration:5 μM Incubation Time:72 hours Result:Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.Cell Viability Assay Cell Line:MDA-MB-231 cells, MiaPaCa-2 cells Concentration:5 μM Incubation Time:72 hours Result:Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.

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Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF

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2762315-06-8

361.46

C21H19N3OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (69.16 mM; 超声助溶 (<60°C)

COc1ccc2c(Nc3cccc(c3)-c3csc(C)n3)cc(C)nc2c1

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(-20℃)

With Ice Pack

≥ 2 years