Epothilone A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Epothilone A 是一种微管稳定剂，EC0.01 为 2 μM。

Epothilone A is a taxol-like microtubule (MT) stabilizing agent.

Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers. The apparent Ki value for Epothilone A is 1.4 μM by Hanes analysis and 0.6 μM by Dixon analysis. Epothilone A, is noted to be highly cytotoxic (IC50=0.05 μM) in vitro when applied to the human T-24 bladder carcinoma cell line. The binding affinity of Epothilone A to tubulin is of the same order of magnitude as the binding affinity of paclitaxel to tubulin based on competition assays. The IC50 for displacement of 100 nM of (3H) paclitaxel from the tubulin binding site is 3.6 μM for paclitaxel, 2.3 μM for Epothilone A, and 3.3 μM for patupilone.

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Epothilone A | Epothilone-A | EpoA

Others

Other Targets

Tubulin

Cancer

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152044-53-6

493.66

C26H39NO6S

>98% (HPLC)

DMSO : 125 mg/mL 253.21 mM;

C[C@H]1CCC[C@H]2O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)/C(=C/c1csc(C)n1)/C

(1R,5S,6S,7R,10S,14S,16S)-6,10-Dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione

(-20℃)

With Ice Pack

≥ 2 years