Lercanidipine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

乐卡地平是二氢吡啶类钙通道阻滞剂。

Lercanidipine hydrochloride is a calcium channel blocker used in the treatment of hypertension.

Western Blot Analysis Cell Line:LPS/IFN-γ-induced VSMC Concentration:1 and 10 μM Incubation Time:24 h Result:Down-regulated LPS/IFN-γ-induced iNOS, MMP-2/-9, NF-kB expression and IkB-a phosphorylation. Decreased cytosolic HMGB1 fraction and extracellular HMGB1 release while increasing nuclear HMGB1 fraction.

Animal Model:Albino male Wistar rats, middle cerebral artery occlusion (MCAo) modelDosage:1, 0.5 and 0.25 mg/kg Administration:Intraperitoneal injection (i.p.), acute administrationResult:Showed neuroprotective effect in focal cerebral ischemic-reperfusion injury model, most effective dose was found to be at 0.5 mg/kg. Significantly attenuated percentage infarct volume, significantly improved the apparent diffusion coefficient. Declined MMP-9 activity significantly in all Lercanidipine treated groups till 240 min post-reperfusion, while MMP-2 activity was inhibited only till 120 min post-reperfusion. Decreased caspase-3 activity significantly in Lercanidipine 15 and 120 min post-reperfusion groups only. Exhibited significant reduction in caspase-9 activity in all groups except at 240 min post-reperfusion group.Animal Model:Male SHRs Dosage:1.92, 0.96, 0.48, 0.24 and 0.12 mg/kg Administration:Oral gavage (p.o.) for once Result:Increased the AOC values of mean arterial pressure in a dose-dependent manner (285.4 mmHg×hour for 1.92 mg) as well as decreased BP.

Lercanidipine hydrochloride | Renovia | Vasodip | R 75

Endocrinology/Hormones

AChR

Calcium Channel

Cardiovascular Disease

——

132866-11-6

648.19

C36H41N3O6·HCl

>98% (HPLC)

DMSO : 50 mg/mL 77.14 mM; H2O : < 0.1 mg/mL

CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(c1ccccc1)c1ccccc1)c1cc(ccc1)[N+](=O)[O-])C(=O)OC.Cl

3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

(-20℃)

With Ice Pack

≥ 2 years