Dichlorphenamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

双氯苯酰胺是一种碳酸酐酶抑制剂，用于治疗青光眼。

Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. Diclofenamide is used to treat glaucoma and therapy-resistant epilepsy.(In Vivo):Dichlorphenamide can reduce IOP locally in male albino rabbits.

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Dichlorphenamide can reduce IOP locally in male albino rabbits. Animal Model:Male albino rabbits (approximately 2.5 kg)Dosage:50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg Administration:Eye drop of 50 μL or Oral gavage of 2 mg/kg or 6 mg/kg, 5 hours Result:Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration, and demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.

Dichlorphenamide | Diclofenamide

GPCR/G Protein

Prostaglandin Receptor

carbonic anhydrase

Others-Field

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120-97-8

305.16

C6H6Cl2N2O4S2

>98% (HPLC)

DMSO : ≥ 28 mg/mL; 91.76 mM

c1c(cc(c(c1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N

4,5-dichlorobenzene-1,3-disulfonamide

(-20℃)

With Ice Pack

≥ 2 years