2-Acetylbenzoic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2-乙酰基苯甲酸在抑制血小板功能和血小板前列腺素 (PG) 合成方面比 2-丙酰氧基苯甲酸更有效，尽管这些药物在抑制前列环素 (PGI2) 合成方面的效力相当。

2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis. (In Vitro):A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-Acetylbenzoic acid had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action.

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GPCR/G Protein

Prostaglandin Receptor

Prostaglandin Receptor

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577-56-0

164.16

C9H8O3

>98% (HPLC)

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CC(=O)c1ccccc1C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years