QS 11

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

QS 11 是 ADP-核糖基化因子 1 (ARFGAP1) 抑制剂的 GTP 酶激活蛋白。

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.(In Vitro):QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking.QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold.QS11 shows potent activity (EC50=0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells.QS11 effectively reduces in vitro migration of metastatic human breast cancer cells.

QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking.QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold.QS11 shows potent activity (EC50=0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells.QS11 effectively reduces in vitro migration of metastatic human breast cancer cells.

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QS11 | QS-11 | QS 11

Angiogenesis

CDK

ARFGAP1

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944328-88-5

567.7

C36H33N5O2

>98% (HPLC)

DMSO : ≥ 100 mg/mL 176.16 mM; H2O : < 0.1 mg/mL

OC[C@H](Cc1ccccc1)Nc1c2c(n(Cc3ccc(c4ccccc4)cc3)cn2)nc(Oc2ccc3CCCc3c2)n1

(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol

(-20℃)

With Ice Pack

≥ 2 years