T56-LIMKi

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

T56-LIMKi 是 LIMK2 的选择性抑制剂。

T-5601640 is a selective LIM kinase 2 (LIMK2) inhibitor.

T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1?/?MEFs with an IC50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers.

T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control.

T-5601640 | T 5601640 | T5601640 | T56LIMKi

GPCR/G Protein

Histamine Receptor

LIMK2

Cancer

——

924473-59-6

389.33

C19H14F3N3O3

>98% (HPLC)

DMSO : ≥ 36 mg/mL; 92.47 mM

Cc1noc(c1)C(=O)Nc1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F

3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide

(-20℃)

With Ice Pack

≥ 2 years