Roquinimex

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Roquinimex (Linomide) 是一种喹啉衍生物免疫刺激剂，可增加 NK 细胞活性和巨噬细胞细胞毒性；抑制血管生成并减少TNFα的分泌。

Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages.

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FCF89 | FCF89 | LS 2616 | Linomide. US brand name: Linomide

Wnt/Notch/Hedgehog

Wnt/beta/catenin

Others

Inflammation/Immunology

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84088-42-6

308.34

C18H16N2O3

>98% (HPLC)

DMSO : ≥ 83.3 mg/mL; 270.17 mM

CN(c1ccccc1)C(=O)C3=C(O)c2ccccc2N(C)C3=O

4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years