β-Elemonic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

β-柠檬酸通过诱导亚倍体细胞和细胞凋亡来抑制增殖，β-柠檬酸的抗癌作用与人 A549 肺癌细胞中 MAPK 信号通路、ROS 激活和谷胱甘肽消耗有关。

Beta-Elemonic acid exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.

β-elemonic acid (1, 3, 10, 20 μM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner. β-elemonic acid (1, 3, 10, 20 μM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 μM. β-elemonic acid (20 μM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. β-elemonic acid (1, 3, 10, 20 μM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.

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Wnt/Notch/Hedgehog

Wnt/beta/catenin

Others

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28282-25-9

454.69

C30H46O3

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (54.98 mM)

CC(=CCCC(C1CCC2(C1(CCC3=C2CCC4C3(CCC(=O)C4(C)C)C)C)C)C(=O)O)C

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(-20℃)

With Ice Pack

≥ 2 years