Ticlopidine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

噻氯匹定是噻吩并吡啶家族中的一种抗血小板化合物，是二磷酸腺苷 (ADP) 受体抑制剂。

Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.(In Vitro):Ticlopidine exhibits activity against human CD39 with apparent Ki,app values of 14 μM.Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12?μM.Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 μM) reducing its effect in the following days.(In Vivo):Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver.

Ticlopidine exhibits activity against human CD39 with apparent Ki,app values of 14 μM.Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12?μM.Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 μM) reducing its effect in the following days. Cell Proliferation Assay Cell Line:Human endothelial cells Concentration:30 and 150 μM Incubation Time:2, 6; 10 days Result:Treated cells grow slower if compared with controls and this effect correlates with the concentration of Ticlopidine in the culture medium.

Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver. Animal Model:Male Sprague-Dawley rats (7-8 weeks old, weighing 270-300 g)Dosage:4 or 10 mg/kg Administration:Orally administered 30 min before oral administration of losartan.Result:The AUC and Cmax of Losartan after oral administration with Losartan and 10 mg/kg Ticlopidine were significantly greater (by 65.0% and 49.4%, respectively) than those of control rats.

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Angiogenesis

EGFR

ADP

Others-Field

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55142-85-3

263.78

C14H14ClNS

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (379.09 mM)

C1CN(Cc2c1scc2)Cc1ccccc1Cl

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(-20℃)

With Ice Pack

≥ 2 years