RO 46-8443

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RO 46-8443 是第一个非肽内皮素 ETB 受体选择性拮抗剂。 RO 46-8443 在结合抑制效力和功能抑制方面对 ETB 受体的选择性高达 2000 倍。

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.

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RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443

Angiogenesis

EGFR

ET-B

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175556-12-4

609.69

C31H35N3O8S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (410.04 mM)

c1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC

4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years