ML 18

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML-18 是一种非肽铃蟾肽受体亚型 3 (BRS-3) 拮抗剂，IC50 为 4.8 μM。

ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). ML-18 inhibits lung cancer growth. ML-18 inhibited the proliferation of lung cancer cells. ML-18 is a nonpeptide BRS-3 antagonist that should serve as a template to improve potency and selectivity.

ML-18 inhibits specific 125I-BA1 (DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2)BB6-14 binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 μM. ML-18 binds with lower affinity to the GRPR and NMBR with IC50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 10 nM BA1 to elevate cytosolic Ca2+ in a reversible manner using lung cancer cells loaded with FURA2-AM. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells. It inhibits the proliferation of lung cancer cells.

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ML-18 | ML 18 | ML18

GPCR/G Protein

Vasopressin Receptor

BRS-3

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1422269-30-4

569.65

C32H35N5O5

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 175.55 mM

COc1ccc(cc1)C1(CCCCC1)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(cc1)[N+](=O)[O-]

(S)-3-(1H-indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide

(-20℃)

With Ice Pack

≥ 2 years