DASA-58

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DASA-58 是一种特异性、有效的丙酮酸激酶 M2 (PKM2) 激活剂。

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

DASA-58 (15 μM; 2 h) potentiates the antitumor effects of other metabolic stressors.?DASA-58 (15 μM; 24 h, 72 h) enhances pyruvate kinase activity in breast cancer cells without a clear effect on proliferation.?DASA-58 (30 μM, 60 μM; 0-72 h) enhances extracellular acidification and lactate levels in BCa cell lines and induce extracellular acidification levels in prostate cancer cell lines.DASA-58 (15 μM, 30 μM; 0-72 h) affects respiration levels in BCa cells without an indication of mitochondrial damage.DASA-58 (15 μM; 0-72 h) not rescues TXNIP levels in any combintion and mitochondrial inhibitors enhance PKM2 effects on activating AMPK signaling (T172 phosphorylation of AMPK) .DASA-58 (15 μM; 0-72 h) leads to depletion in TXNIP levels independent of AMPK and ER signaling, and not through enhanced proteasomal degradation but rather depleted upstream glycolytic intermediates. Cell Viability Assay Cell Line:Five breast cancer cell lines (BCa cells) (MDA MB 231, MDA MB 468, HCC 1443, T47-D, MCF7, LnCap, PC3, and DU145)Concentration:15 μM Incubation Time:2 h Result:Could be exploited by other metabolic stressors.Western Blot Analysis Cell Line:BCa cells Concentration:15 μM Incubation Time:24 h, 72 h Result:Showed comparable PKM2 protein levels in five breast cancer cell lines, except HCC1443 cells and MDA MB 468 that showed the highest and lowest PKM2 protein levels, respectively.

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Angiogenesis

CDK

PKM2

Cancer

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1203494-49-8

453.53

C19H23N3O6S2

>98% (HPLC)

DMSO : ≥ 35 mg/mL 77.17 mM

c1(cc(ccc1)S(=O)(=O)N1CCN(CCC1)S(=O)(=O)c1cc2OCCOc2cc1)N

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(-20℃)

With Ice Pack

≥ 2 years