NSC 86429

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SU-4312，也称为 DMBI，是一种有效的选择性 VEGFR 和 PDGFR 酪氨酸激酶抑制剂（IC50 值分别为 0.8 和 19.4 μM）。

SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.

Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers.

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SU-4312 | SU 4312 | SU4312. DMBI | NSC 86429

Cytoskeleton/Cell Adhesion Molecules

Akt

PDGFR| VEGFR

Cancer

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5812-07-7

264.33

C17H16N2O

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (189.16 mM)

CN(C)C1=CC=C(C=C1)/C=C\2/C3=CC=CC=C3NC2=O

3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one

(-20℃)

With Ice Pack

≥ 2 years