Sotalol hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸索他洛尔是一种肾上腺素能β-拮抗剂，用于治疗危及生命的心律失常。

Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.(In Vivo):Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin.

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Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin. Animal Model:20-25 g female Swiss mice Dosage:100 mg/kg Administration:Administered intraperitoneally Result:Significantly decreased the brain concentrations of Lamotrigine and increased those of Oxcarbazepine and Topiramate.

Betapace | MJ1999

Endocrinology/Hormones

Adrenergic Receptor

β-adrenergic receptor| Potassium Channel

Cardiovascular Disease

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959-24-0

308.82

C12H21ClN2O3S

>98% (HPLC)

Water: 62 mg/mL (200.76 mM); DMSO: 62 mg/mL (200.76 mM)

Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

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(-20℃)

With Ice Pack

≥ 2 years