Nicergoline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

尼麦角林是一种麦角衍生物，用于治疗老年痴呆症和其他血管源性疾病。

Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.(In Vitro):Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death.Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia.(In Vivo):Nicergoline (10 mg/kg; i.v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease.Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice.

Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death.Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia.

Nicergoline (10 mg/kg; i.v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease.Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice. Animal Model:3×Tg-AD mice (male, 28-35 g, 6 weeks) with the Alzheimer's disease Dosage:10 mg/kg Administration:I.v. once daily for 60 days Result:Improved neurogenesis and cognitive competence.Decreased the degree of dementia.Downregulated pathogenic Aβ-42 and -40 peptides and APP in the hippocampi.Increased Levels of the neuroprotective forkhead box protein P2 (Foxp2), Src homology 2-containing inositol phosphatase (SxIP) and end-binding proteins (EB) in the hippocampi.Exhibited marked differences in the dispersion of the pyramidal cell layer between the nicergoline-treated and control groups.

Nicergoline, Nicotergoline, Nimergoline, Sermion

Endocrinology/Hormones

Adrenergic Receptor

Adrenergic Receptor

Neurological Disease

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27848-84-6

484.39

C24H26BrN3O3

>98% (HPLC)

Soluble in DMSO

O=C(C1=CC(Br)=CN=C1)OC[C@H](C[C@]23OC)CN(C)[C@]3([H])CC4=CN(C)C5=C4C2=CC=C5

[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate

(-20℃)

With Ice Pack

≥ 2 years