NSC 14613

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PluriSln 1(NSC 14613) 是硬脂酰辅酶 A 去饱和酶 (SCD1) 的抑制剂，该酶是油酸生物合成中的关键酶，揭示了 hPSC 脂质代谢的独特作用。

PluriSln 1(NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.

PluriSIn 1, a small-molecule inhibitor of stearoyl-coA desaturase (SCD), on induced pluripotent stem cells (iPS)-derived cardiomyocytes (CM). PluriSIn 1 treatment significantly decreases the mRNA and protein level of Nanog, a marker for both cell pluripotency and tumor progression; importantly, we provide evidence that PluriSIn 1 treatment at 20 μM for 1 day significantly induces the apoptosis of Nanog-positive iPS derivates (iPSD). In addition, PluriSIn 1 treatment at 20 μM for 4 days diminished Nanog-positive stem cells in cultured iPSD while not increasing apoptosis of iPS-derived CM. To investigate whether PluriSIn 1 treatment prevents tumorigenicity of iPSD after cell transplantation, we intramyocardially injected PluriSIn 1- or DMSO-treated iPSD in a mouse model of myocardial infarction (MI). DMSO-treated iPSD readily formed Nanog-expressing tumors 2 weeks after injection, which is prevented by treatment with PluriSIn 1. Moreover, treatment with PluriSIn 1 does not change the expression of cTnI, α-MHC, or MLC-2v, markers of cardiac differentiation (P>0.05, n=4). Importantly, PluriSIn 1-treated iPS-derived CM exhibits the ability to engraft and survive in the infarcted myocardium.

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NSC 14613 | N’-phenyl-hydrazine-Isonicotinic acid

Metabolic Enzyme/Protease

Dehydrogenase

SCD

Cancer

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91396-88-2

213.24

C12H11N3O

>98% (HPLC)

DMSO: 43 mg/mL (201.65 mM)

O=C(NNC1=CC=CC=C1)C2=CC=NC=C2

N'-phenylisonicotinohydrazide

(-20℃)

With Ice Pack

≥ 2 years