DHODH-IN-13

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DHODH-IN-13 是 A771726 的羟基呋喃类似物。

DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.

DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds.

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Metabolic Enzyme/Protease

Dehydrogenase

E3 Ligase Ligand-Linker Conjugate

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1364791-86-5

273.171

C10H6F3N3O3

>98% (HPLC)

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FC(F)(F)c1ccc(NC(=O)c2no[nH]c2=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years