Benzthiazide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苯并噻嗪用于治疗高血压和水肿。与其他噻嗪类化合物一样，苯并噻嗪类化合物会促进体内水分流失（利尿剂）。

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. (In Vitro):Benzthiazide (0.4, 2, 10?μM) suppresses proliferation of cancer cell under hypoxic conditions in a dose-dependent mannerBenzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively.(In Vivo):Benzthiazide (1, 1.5 mg/100 g BW) causes a marked decrease in urinary calcium excretion and the dissociation of calcium and sodium excretion in hyperprolactinemic rats.

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Benzthiazide | Benzothiazide | Dihydrex | Aquatag | Diucen | Exna | Edemax | Foven | Dytide

Membrane Transporter/Ion Channel

Carbonic Anhydrase

Carbonic anhydrase

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91-33-8

431.94

C15H14ClN3O4S3

>98% (HPLC)

DMSO: 10 mM

O=S(N=C1CSCC2=CC=CC=C2)(C3=CC(S(=O)(N)=O)=C(Cl)C=C3N1)=O

Benzthazide; 3-[(benzylsulfanyl)methyl]-6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

(-20℃)

With Ice Pack

≥ 2 years