Benzolamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苯甲酰胺有效抑制碳酸酐酶和海马锥体神经元中的低阈值钙电流。

Benzolamide inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.(In Vitro):Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively. Benzolamide shows selectivity for CAS3 with a Ki of 54 nM over CAS1 with a Ki of 2115 nM and CAS2 with a Ki of 410 nM.(In Vivo):Administration of 90 μmol/kg Benzolamide decreases brain pH and suppresses electrographic post-asphyxia seizures in rats.

——

Animal Model:Male and female Wistar Han rats (11-day-old).Dosage:90 μmol/kg Administration:A single i.p.Result:Induced a fast brain acidosis of a comparable magnitude.Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.

CL 11366 | CL-11366 | CL11366 | W 1803 | W-1803

Membrane Transporter/Ion Channel

Carbonic Anhydrase

——

——

——

3368-13-6

320.36

C8H8N4O4S3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (780.35 mM)

NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1

——

(-20℃)

With Ice Pack

≥ 2 years