Motesanib diphosphate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的、口服生物可利用的 VEGFR1/2/3、PDGFR 和 c-Kit 多激酶抑制剂，IC50 分别为 2-6 nM、84 nM 和 8 nM。

A potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively; also displays activity against Ret (IC50=59 nM), no activities against EGFR, Src, and p38; inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro; potently inhibits VEGF-induced angiogenesis in the rat models.Lung Cancer Phase 3 Discontinued.

Motesanib Diphosphate (AMG 706 Diphosphate) has broad activity against the human VEGFR family, and displays over 1000-fold selectivity against EGFR, Src, and p38 kinase.Motesanib Diphosphate (AMG 706 Diphosphate) significantly inhibits VEGF-induced cellular proliferation of HUVECs with an IC50 of 10 nM, while displaying little effect at bFGF-induced proliferation with an IC50 of >3,000 nM. Motesanib Diphosphate (AMG 706 Diphosphate) also potently inhibits PDGF-induced proliferation and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not effective against the EGF-induced EGFR phosphorylation and cell viability of A431 cells. Although displaying little antiproliferative activity on cell growth of HUVECs alone, Motesanib Diphosphate (AMG 706 Diphosphate) treatment significantly sensitizes the cells to fractionated radiation.

Motesanib Diphosphate (AMG 706 Diphosphate) (100 mg/kg) significantly inhibits VEGF-induced vascular permeability in a time-dependent manner. Oral administration of Motesanib twice daily or once daily potently inhibits, in a dose-dependent manner, VEGF-induced angiogenesis using the rat corneal model with ED50 of 2.1 mg/kg and 4.9 mg/kg, respectively. Motesanib Diphosphate (AMG 706 Diphosphate) induces a dose-dependent tumor regression of established A431 xenografts by selectively targeting neovascularization in tumor cells. Motesanib Diphosphate (AMG 706 Diphosphate) in combination with radiation displays significant anti-tumor activity in head and neck squamous cell carcinoma (HNSCC) xenograft models. Motesanib Diphosphate (AMG 706 Diphosphate) treatment also induces significant dose-dependent reductions in tumor growth and blood vessel density of MCF-7, MDA-MB-231, or Cal-51 xenografts, which can be markedly enhanced when combined with docetaxel or tamoxifen.

AMG-706 | Motesanib | AMG706 | AMG 706

Angiogenesis

VEGFR

Kit|VEGFR1|VEGFR2|VEGFR2/Flk1|VEGFR3

Cancer

Lung Cancer

857876-30-3

569.4413

C22H29N5O9P2

>98% (HPLC)

10 mM in DMSO

OP(O)(O)=O.OP(O)(O)=O.CC1(C)CNC2=C1C=CC(NC(=O)C1=C(NCC3=CC=NC=C3)N=CC=C1)=C2

3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-, phosphate (1:2)

(-20℃)

With Ice Pack

≥ 2 years