Idazoxan hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苯并二恶烷连接的咪唑，具有 α-2 肾上腺素受体拮抗剂活性。

A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.(In Vivo):Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol.

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Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol. Animal Model:Male CD-COBS rats injected with 1?mg/kg haloperidol Dosage:0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0?mg/kg Administration:Subcutaneous injection; for 1 hour Result:Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg.

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Endocrinology/Hormones

Adrenergic Receptor

Adrenergic Receptor

Neurological Disease

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79944-56-2

240.69

C11H12N2O2·HCl

>98% (HPLC)

Water: 100 mM

Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1

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(-20℃)

With Ice Pack

≥ 2 years