Nebivolol hydrochloride ( Nebivolol HCl | Nebivolol Hydrochloride | Silostar | Bystolic, R-67145 | R 67145 | R67145 )

产品货号. M12131 CAS No. 152520-56-4

Nebivolol HydroHClide 选择性抑制 β1-肾上腺素能受体，IC50 为 0.8 nM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
10MG	￥250	有现货
25MG	￥444	有现货
50MG	￥770	有现货
100MG	￥1197	有现货
200MG	￥1782	有现货
500MG	￥3591	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥169	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Nebivolol hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Nebivolol HydroHClide 选择性抑制 β1-肾上腺素能受体，IC50 为 0.8 nM。
产品描述

Nebivolol hydrochloride selectively inhibits?β1- adrenergic receptor with?IC50?of 0.8 nM.(In Vitro):Nebivolol hydrochloride improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties.Nebivolol hydrochloride (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM.Nebivolol hydrochloride (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis.Nebivolol hydrochloride (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs
体外实验

Cell Proliferation Assay Cell Line:haCSMCs (human coronary smooth muscle cells) and haECs (endothelial cells)Concentration:0.1 μM-10 μM Incubation Time:1, 2, 4, 7 or 14 days Result:Reduced proliferation in HaECs and HaCSMCs in a concentration- and time-dependent.Apoptosis Analysis Cell Line:haCSMCs and haECs Concentration:0.1 μM-10 μM Incubation Time:24 h Result:Induced a moderate apoptosis in concentration-dependent and showed a decrease of haCSMCs in the S-phase by 66%.
体内实验

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同义词

Nebivolol HCl | Nebivolol Hydrochloride | Silostar | Bystolic, R-67145 | R 67145 | R67145
通路

Endocrinology/Hormones
靶点

Adrenergic Receptor
受体

β1-adrenoceptor
研究领域

Cardiovascular Disease
适应症

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化学信息

CAS Number

152520-56-4
分子量

441.9
分子式

C22H25F2NO4·HCl
纯度

>98% (HPLC)
溶解度

DMSO: 88 mg/mL (199.14 mM)
SMILES

O[C@@H]([C@H]1CCC2=C(O1)C=CC(F)=C2)CNC[C@H](O)[C@@H]3CCC4=C(O3)C=CC(F)=C4.[H]Cl
化学全称

(R)-1-((R)-6-fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol hydrochloride