ML406

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML406 是一种小分子 Mtb bioA（DAPA 合酶）酶抑制剂 (IC50=30 nM)，具有抗结核活性。

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD; exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.

ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB).

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ML406 | ML-406 | ML 406

GPCR/G Protein

Antibacterial

Antibacterial

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774589-47-8

352.39

C20H20N2O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (283.78 mM)

CC(C1=CC=C(N2CCN(C(C3=CC=C(OCO4)C4=C3)=O)CC2)C=C1)=O

1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone

(-20℃)

With Ice Pack

≥ 2 years