021-51111890
购物车（）
sales@molnova.cn
Arteether
CAS No. 75887-54-6
Arteether ( Artemotil | Dihydroartemisinin ethyl ether | NSC 665971 )
产品货号. M15885 CAS No. 75887-54-6
Artemotil (β-Arteether) 具有抗疟疾活性，可用于研究耐 Plasmodium falciparum 的恶性疟原虫疟疾，IC50 值为 1.61 nM。Artemotiltil 对大鼠，狗和猴子具有 CNS 神经毒性和厌食毒性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥228 | 有现货 |
|
生物学信息
-
产品名称Arteether
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Artemotil (β-Arteether) 具有抗疟疾活性，可用于研究耐 Plasmodium falciparum 的恶性疟原虫疟疾，IC50 值为 1.61 nM。Artemotiltil 对大鼠，狗和猴子具有 CNS 神经毒性和厌食毒性。
-
产品描述Arteether, a new antimalarial drug.(In Vitro):The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.(In Vivo):Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7).
-
体外实验The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.
-
体内实验Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7). Animal Model:Sprague-Dawley male rats (220-280 g)Dosage:25 mg/kg; 1 mL/kg body weight Administration:Intravenous injection; daily; for 7 days Result:Anorectic toxicity was observed, and that caused significant reductions in food consumption and body weight after day 2.
-
同义词Artemotil | Dihydroartemisinin ethyl ether | NSC 665971
-
通路Autophagy
-
靶点CCR
-
受体CCL4| CCL5| CXCL10| CXCL9
-
研究领域Infection
-
适应症——
化学信息
-
CAS Number75887-54-6
-
分子量312.4
-
分子式C17H28O5
-
纯度>98% (HPLC)
-
溶解度Soluble in DMSO
-
SMILESC[C@H]1[C@@H](OCC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3
-
化学全称(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Dwivedi H, et al. Parasitology. 2016, 143(12):1557-68.
产品手册
关联产品
-
CCR3 antagonist 1
CCR3 antagonist 1 是一种有效的 CCR3 拮抗剂，主要用于免疫病和炎症的研究。
-
Plozalizumab
Plozalizumab (MLN-1202) 是一种特异性的人源化抗 CCR2 抗体。Plozalizumab 可用于恶性黑色素瘤研究。
-
CCR6 inhibitor 1
CCR6 inhibitor 1 是一种有效、选择性的 CCR6 抑制剂，对猴子和人 CCR6 的 IC50 值分别为 0.45 和 6 nM，对其选择性远高于人 CCR1 (IC50，> 30000 nM) 和 CCR7 (IC50，9400 nM)。CCR6 inhibitor 1 显著抑制 ERK 磷酸化。可用于自身免疫病和癌症的研究。
