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Arteether
CAS No. 75887-54-6
Arteether ( Artemotil | Dihydroartemisinin ethyl ether | NSC 665971 )
产品货号. M15885 CAS No. 75887-54-6
Artemotil (β-Arteether) 具有抗疟疾活性，可用于研究耐 Plasmodium falciparum 的恶性疟原虫疟疾，IC50 值为 1.61 nM。Artemotiltil 对大鼠，狗和猴子具有 CNS 神经毒性和厌食毒性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥228 | 有现货 |
|
生物学信息
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产品名称Arteether
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Artemotil (β-Arteether) 具有抗疟疾活性，可用于研究耐 Plasmodium falciparum 的恶性疟原虫疟疾，IC50 值为 1.61 nM。Artemotiltil 对大鼠，狗和猴子具有 CNS 神经毒性和厌食毒性。
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产品描述Arteether, a new antimalarial drug.(In Vitro):The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.(In Vivo):Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7).
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体外实验The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.
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体内实验Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7). Animal Model:Sprague-Dawley male rats (220-280 g)Dosage:25 mg/kg; 1 mL/kg body weight Administration:Intravenous injection; daily; for 7 days Result:Anorectic toxicity was observed, and that caused significant reductions in food consumption and body weight after day 2.
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同义词Artemotil | Dihydroartemisinin ethyl ether | NSC 665971
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通路Autophagy
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靶点CCR
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受体CCL4| CCL5| CXCL10| CXCL9
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研究领域Infection
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适应症——
化学信息
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CAS Number75887-54-6
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分子量312.4
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分子式C17H28O5
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESC[C@H]1[C@@H](OCC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3
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化学全称(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Dwivedi H, et al. Parasitology. 2016, 143(12):1557-68.
产品手册
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