Aniracetam

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aniracetam(Ro 13-5057) 是一种促智药和神经保护化合物，选择性调节 AMPA 受体和 nAChR。

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.(In Vitro):Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.(In Vivo):Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance.

Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.

Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance. Animal Model:Pyramidal neurons from male Wistar rats Dosage:1 mM Administration:30-75 min Result:Potentiated the iQA receptors existing in the brain and produced remarkable facilitation of the native synaptic transmission.Animal Model:Male rats (100-120 g; hypercapnia induced by pure CO2)Dosage:10, 30, 50 and 100 mg/kg Administration:p.o.; single dosage (60 min before hypercapnia)Result:Significantly prevented the CO2-induced impairment of acquisition at 30 and 50 mg/kg.Animal Model:Male rats and male mice (100-120 g and 21-25 g; 0.5 mg/kg Scopolamine-induced transient disruption of the memory of a passive avoidance procedure)Dosage:30, 50, 100 and 300 mg/kg,Administration:p.o.; single dosage Result:Significantly increased the percentage of rats showing passive avoidance 2 h after Scopolamine (HY-N0296) at 50 and 100 mg/kg.

Memodrin | Ro 13-5057 | Sarpul

Endocrinology/Hormones

5-HT Receptor

5-HT| Dopamine| AMPA| GluR

Neurological Disease

——

72432-10-1

219.24

C12H13NO3

>98% (HPLC)

Ethanol: 18 mg/mL (82.1 mM); DMSO: 44 mg/mL (200.69 mM)

O=C1N(C(C2=CC=C(OC)C=C2)=O)CCC1

1-(4-methoxybenzoyl)pyrrolidin-2-one

(-20℃)

With Ice Pack

≥ 2 years