Dapoxetine HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dapoxetine (LY-210448) hydrochloride 是一种具有口服活性的选择性血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI)。Dapoxetine hydrochloride 可用于早泄 (PE) 的相关研究。

Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor used for the therapy of premature ejaculation.(In Vitro):Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine?dopamine.Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.(In Vivo):Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats.

Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine? dopamine.Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.

Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats. Animal Model:Adult male Wistar rats Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg Administration:Oral gavage; 1-10 mg/kg; once daily Result:Reverted most of the changes made by testosterone injection

Dapoxetine hydrochloride | LY-210448 hydrochloride | LY-210448 | Priligy

Endocrinology/Hormones

5-HT Receptor

5-HT

Neurological Disease

Premature ejaculation

129938-20-1

341.87

C21H23NO·HCl

>98% (HPLC)

DMSO:34.2 mg/mL (100 mM);water:25.6 mg/mL (75 mM)

Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years