NSC-66811

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的 MDM2-p53 相互作用抑制剂，Ki 为 120 nM，可激活癌细胞中的 p53。

A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.

NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53. Western Blot Analysis Cell Line:HCT-116 (p53+/+ and p53-/-) cells.Concentration:0, 5, 10, 20 μM.Incubation Time:48 h.Result:Dose-dependently induced the accumulation of p53, MDM2, and p21cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53. Had no effect on the levels for p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line.

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NSC66811 | NSC 66811

Apoptosis

MDM2-p53

MDM2-p53

Cancer

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6964-62-1

340.426

C23H20N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (293.75 mM)

OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4

2-methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol

(-20℃)

With Ice Pack

≥ 2 years