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PhiKan 083
CAS No. 880813-36-5
PhiKan 083 ( —— )
产品货号. M22064 CAS No. 880813-36-5
PhiKan 083 是一种咔唑衍生物，PhiKan 083 可降低 Ln229 细胞工程变体的细胞活力，与 NSC 123127 (1 μM) 结合可增强 Ln229 细胞所有变体的促凋亡活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥847 | 有现货 |
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| 10MG | ￥1378 | 有现货 |
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| 25MG | ￥2465 | 有现货 |
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| 50MG | ￥3701 | 有现货 |
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| 100MG | ￥5022 | 有现货 |
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| 500MG | ￥10080 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥932 | 有现货 |
|
生物学信息
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产品名称PhiKan 083
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PhiKan 083 是一种咔唑衍生物，PhiKan 083 可降低 Ln229 细胞工程变体的细胞活力，与 NSC 123127 (1 μM) 结合可增强 Ln229 细胞所有变体的促凋亡活性。
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产品描述PhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W).
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体外实验PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells.PhiKan 083 slows down its thermal denaturation rate.PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells. PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). Cell Viability Assay Cell Line:Ln229, Ln229-p53-wt, Ln229-p53-Y220C, Ln229-p53-G245S, Ln229-p53-R282W cells Concentration:125 μMIncubation Time:48 hours Result:Caused ～70 ± 5% reduction in cell viability of variants of Ln229 cells.
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体内实验——
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同义词——
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通路Apoptosis
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靶点MDM2-p53
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受体p53/MDM2
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研究领域——
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适应症——
化学信息
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CAS Number880813-36-5
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分子量238.33
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分子式C16H18N2
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纯度>98% (HPLC)
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溶解度DMSO:115 mg/mL (482.52 mM; Need ultrasonic); Ethanol:100 mg/mL (419.59 mM; Need ultrasonic)
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SMILESCCN1C2=CC=CC=C2C2=C1C=CC(CNC)=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511.2. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.3. Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74.
