Phentolamine mesilate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Phentolamine Mesylate 是一种非选择性 α-肾上腺素能拮抗剂。

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.(In Vitro):Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi?cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.(In Vivo):Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.

Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.?Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi?cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.

Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.

Regitine | Vasomax

Endocrinology/Hormones

Adrenergic Receptor

α-adrenergic receptor

Cardiovascular Disease

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65-28-1

377.46

C17H19N3O·CH4O3S

>98% (HPLC)

Ethanol: 76 mg/mL (201.34 mM); Water: 76 mg/mL (201.34 mM); DMSO: 76 mg/mL (201.34 mM)

CS(O)(=O)=O.CC1=CC=C(C=C1)N(CC1=NCCN1)C1=CC(O)=CC=C1

3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol methanesulfonate

(-20℃)

With Ice Pack

≥ 2 years