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L-Phenylalanine
CAS No. 63-91-2
L-Phenylalanine ( —— )
产品货号. M15427 CAS No. 63-91-2
L-苯丙氨酸是 α2δ 钙通道的拮抗剂，Ki 为 980 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥159 | 有现货 |
|
| 500MG | ￥318 | 有现货 |
|
| 1G | ￥372 | 有现货 |
|
生物学信息
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产品名称L-Phenylalanine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述L-苯丙氨酸是 α2δ 钙通道的拮抗剂，Ki 为 980 nM。
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产品描述L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM Target: Calcium Channel L-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins.(In Vitro):DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM.(In Vivo):The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.
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体外实验DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine.L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM.
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体内实验The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.
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同义词——
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通路GPCR/G Protein
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靶点Calcium Channel
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受体α2δ calcium channels
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研究领域Metabolic Disease
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适应症——
化学信息
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CAS Number63-91-2
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分子量165.19
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分子式C9H11NO2
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纯度>98% (HPLC)
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溶解度H2O: ≥ 46 mg/Ml
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SMILESN[C@@H](CC1=CC=CC=C1)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mortell, K.H., et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett, 2006. 16(5): p. 1138-41.
2. Glushakov, A.V., et al., Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry, 2002. 7(4): p. 359-67.
3. Glushakov, A.V., et al., L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res, 2003. 72(1): p. 116-24.
4. Glushakov, A.V., et al., Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain, 2005. 128(Pt 2): p. 300-7.
5. Moller, H.E., et al., Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria. Pediatrics, 2003. 112(6 Pt 2): p. 1580-3.
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