Lidocaine Hydrochloride hydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Lidocaine (Lignocaine) hydrochloride hydrate 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride hydrate 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine hydrochloride hydrate 是一种酰胺衍生物，可用于研究室性心律失常。

Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.(In Vitro):Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation.Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10?nM and treatment time 48?hours.Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate.Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.(In Vivo):Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.

Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation. Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10?nM and treatment time 48?hours. Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate. Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly. Cell Proliferation Assay Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Decreased significantly cell proliferation.Cell Viability Assay Cell Line:The human gastric cancer cell line MKN45 Concentration:1, 5 and 10?nMIncubation Time:24, 48, 72 hours Result:Inhibited MKN45 cell viability.Apoptosis Analysis Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Increased significantly the apoptotic cell rate.Western Blot Analysis Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Down-regulated Cyclin D1 and up-regulated p21 expression significantly.

Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.

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Angiogenesis

EGFR

EGFR| Sodium Channel

Cardiovascular Disease

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6108-05-0

288.82

C14H22N2O·HCl·H2O

>98% (HPLC)

DMSO: 10 mM

O.Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years