Camostat mesilate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Camostat 是一种胰蛋白酶样蛋白酶抑制剂，抑制气道上皮钠通道 (ENaC) 功能，IC50 为 50 nM，对胰蛋白酶、前列腺素和 matriptase 的作用较弱。

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

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Animal Model:6-8 week old female BALB/c mice (lethal SARS-CoV infection model)Dosage:30 mg/kg Administration:P.o.; twice a day for 9 days Result:Effective in protecting mice against death due to a lethal infection by SARS-CoV, with a survival rate of ～60%.

Foipan | FOY 305

Membrane Transporter/Ion Channel

Sodium Channel

epithelial sodium channel (ENaC)

Metabolic Disease

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59721-29-8

494.52

C21H26N4O8S

>98% (HPLC)

Water: 10 mg/mL (20.22 mM); DMSO: 99 mg/mL (200.19 mM)

CS(O)(=O)=O.CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(C=C2)N=C(N)N)C=C1

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(-20℃)

With Ice Pack

≥ 2 years