PF-06305591 (PF06305591) 是一种有效的、高选择性的 NaV1.8 阻断剂，IC50 为 15 nM，对其他钠通道亚型、K+ 通道和 Ca2+ 通道没有显着活性。

Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperisone HCl is used to treat recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, dystonia symptoms, cone tension syndrome, multiple sclerosis myospasm and myelitis. silperisone is a sodium channel protein type 2 alpha channel blocker. silperisone is an organosilicon similar to tolperisone, an organosilicon compound with centrally acting muscle relaxant properties.

达克罗宁是一种口腔麻醉剂，可在 Sucrets 中找到，这是一种非处方润喉糖。