Azelastine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Azelastine 是一种有效的第二代选择性组胺拮抗剂。

Azelastine is a potent, second-generation, selective, histamine antagonist.

Azelastine can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling.Cell Proliferation Assay Cell Line:Human nasal epithelial cells (HNEpC)Concentration:100 μM, 400 μM Incubation Time:21 days Result:Inhibited HNEpC growth.Western Blot Analysis Cell Line:Human nasal epithelial cells (HNEpC) Concentration:100 μM Incubation Time:7 days Result:Significantly up-regulated the H1R, M1R and M3R levels.

Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model. Animal Model:Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats modelDosage:4 mg/kg Administration:Oral administration, daily, for 8 weeks Result:Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.

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GPCR/G Protein

Histamine Receptor

H1 receptor

Inflammation/Immunology

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58581-89-8

381.9

C22H24ClN3O

>98% (HPLC)

Soluble in DMSO

CN1CCCC(CC1)N1N=C(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2C1=O

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(-20℃)

With Ice Pack

≥ 2 years