Theophylline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

茶碱是一种甲基化黄嘌呤衍生物；竞争性非选择性磷酸二酯酶抑制剂和非选择性腺苷受体拮抗剂。

Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.(In Vitro):Theophylline (1,3-Dimethylxanthine) (1-1000 μM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries.Theophylline (1,3-Dimethylxanthine) (10 μg/mL; 24 h; eosinophils) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2.Theophylline (1,3-Dimethylxanthine) (0-500 μM; 2 h; A549 cells) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner.Theophylline (1,3-Dimethylxanthine) (0-1000 μM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression.(In Vivo):Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO.

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1,3-Dimethylxanthine | NSC 2066

Endocrinology/Hormones

AChR

Adenosine receptor| HDAC2| PDE

Other Indications

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58-55-9

180.16

C7H8N4O2

>98% (HPLC)

soluble in Water

CN1C2=C(NC=N2)C(=O)N(C)C1=O

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(-20℃)

With Ice Pack

≥ 2 years