Cornuside

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cornuside 具有免疫调节活性。Cornuside 抑制人内皮细胞中细胞因子诱导的促炎分子和粘附分子的表达水平。

Cornuside has immunomodulatory activity . Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.

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Endocrinology/Hormones

AChR

JNK1/2|ERK1/2

Inflammation/Immunology

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131189-57-6

542.49

C24H30O14

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (184.34 mM)

COC(=O)C1=COC(C(C1CCOC(=O)C2=CC(=C(C(=C2)O)O)O)C=C)OC3C(C(C(C(O3)CO)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years