Mivacurium chloride ( —— )

产品货号. M23275 CAS No. 106861-44-3

米库氯铵是一种非去极化、短期快速神经肌肉阻滞剂，因此用作麻醉剂，在小型外科手术中提供骨骼肌松弛作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥336	有现货
5MG	￥539	有现货
10MG	￥782	有现货
25MG	￥1113	有现货
50MG	￥1755	有现货
100MG	￥2665	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥891	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Mivacurium chloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

米库氯铵是一种非去极化、短期快速神经肌肉阻滞剂，因此用作麻醉剂，在小型外科手术中提供骨骼肌松弛作用。
产品描述

Mivacurium chloride is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.(In Vitro):Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA.(In Vivo):Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature.Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.
体外实验

Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA.
体内实验

Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature. Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.
同义词

——
通路

Endocrinology/Hormones
靶点

AChR
受体

nAChR
研究领域

——
适应症

——

化学信息

CAS Number

106861-44-3
分子量

1100.17
分子式

C58H80Cl2N2O14
纯度

>98% (HPLC)
溶解度

DMSO:100 mg/ml (90.9 mM); Ethanol:100 mg/ml (90.9 mM); Water:100 mg/ml (90.9 mM)
SMILES

C[N+](CCCOC(CC/C=C/CCC(OCCC[N+](C)(CC1)[C@H](Cc(cc2OC)cc(OC)c2OC)c(cc2OC)c1cc2OC)=O)=O)(CC1)[C@H](Cc(cc2OC)cc(OC)c2OC)c(cc2OC)c1cc2OC.[Cl-].[Cl-]
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Delu Che, et al. Mivacurium Induce Mast Cell Activation and Pseudo-Allergic Reactions via MAS-related G Protein Coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128.

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