EX 527 (Selisistat)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EX 527 是一种有效的选择性 SIRT1 抑制剂，IC50 为 38 nM，对 SIRT2 和 SIRT3 的选择性超过 200 倍。

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.(In Vitro):Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.(In Vivo):Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).

Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.

Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).

Selisistat

Chromatin/Epigenetic

Sirtuin

SIRT1

Cancer

——

49843-98-3

248.71

C13H13ClN2O

>98% (HPLC)

DMSO:50 mg/mL (201.03 mM); Ethanol:18 mg/mL (72.37 mM); Water:<1 mg/mL (<1 mM)

O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

(-20℃)

With Ice Pack

≥ 2 years