Cytisine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cytisinicline (Cytisine) 是一种生物碱，是 α4β2 烟碱乙酰胆碱能受体 (α4β2 nAChRs) 的部分激动剂，也是包含 β4 受体和 α7 受体的偏完全性激动剂。医学上已被用于帮助戒烟。

Cytisine is an alkaloid that is found naturally in several plant genera such as Laburnum and Cytisus of the family Fabaceae. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost. (In Vitro):Cytisinicline (Cytisine) (2.5, 5 and 10 mM) is capable of inducing apoptosis in HepG2 cells.Treatment with Cytisinicline (Cytisine) increases the percentage of cells in the sub-G1 phase (P<0.01). The preincubation of HepG2 cells with Cytisinicline (Cytisine) (2.5, 5 and 10 mM) significantly increases the sub-G1 cell population.(In Vivo):Cytisinicline (Cytisine) (5 mg/kg, i.p.) eat less and gain less weight than those that receive the vehicle.Total pellet intake increases during Cytisinicline (Cytisine) substitution relative to nicotine and animals self-administered Cytisine significantly less than nicotine.

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Baptitoxin | Citizin | HSDB 3560 | Laburnin | NSC 407282 | Sophorin | Cytisine | Cytisinicline

Endocrinology/Hormones

AChR

nAChR

Neurological Disease

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485-35-8

190.25

C11H14N2O

>98% (HPLC)

Ethanol: 38 mg/mL (199.74 mM); Water: 38 mg/mL (199.74 mM); DMSO: 38 mg/mL (199.74 mM)

O=C1C=CC=C2N1C[C@]3([H])CNC[C@@]2([H])C3

(1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one

(-20℃)

With Ice Pack

≥ 2 years