Arecoline HBr

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Arecoline Hydrobromide 是一种毒蕈碱乙酰胆碱受体激动剂。

Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.(In Vitro):Arecoline hydrobromide induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline hydrobromide-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline hydrobromide upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase.

Arecoline hydrobromide induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline hydrobromide-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline hydrobromide upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase.

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Endocrinology/Hormones

AChR

mAChR

Neurological Disease

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300-08-3

236.11

C8H13NO2·HBr

>98% (HPLC)

Ethanol: 10 mg/mL (42.35 mM); Water: 47 mg/mL (199.05 mM); DMSO: 47 mg/mL (199.05 mM)

Br.COC(=O)C1=CCCN(C)C1

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(-20℃)

With Ice Pack

≥ 2 years