4-Methylpyrazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

甲吡唑用作已确诊或疑似甲醇或乙二醇中毒的解毒剂。

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. (In Vivo):Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice.

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Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice Animal Model:Male CD-1 mice weighing 18-25 gDosage:25 mg/kg Administration:IP; single dose Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).

4-Methylpyrazole

Endocrinology/Hormones

AChR

ADH| CAT

Other Indications

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7554-65-6

82.1

C4H6N2

>98% (HPLC)

Water: 146 mg/mL

CC1=CNN=C1

4-methyl-1H-pyrazole

(-20℃)

With Ice Pack

≥ 2 years