KH 176 ( KH176 )

产品货号. M13449 CAS No. 2162149-24-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

KH 176
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

KH176是Trolox的化学实体衍生物和小分子ROS-氧化还原调节剂。
产品描述

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders; retains brain microstructural coherence in the external capsule in Ndufs4 -/- mice and normalizes the increased lipid peroxidation in this area and the cerebral cortex, significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.Other Indication Phase 2 Clinical.
体外实验

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体内实验

Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4?/? mice. Animal Model:Ndufs4?/? mice (Leigh Disease model).Dosage:10?mg/kg.Administration:IP, daily (PD14-PD45, 32 days).Result:Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.
同义词

KH176
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Other Indications
适应症

Other Disease

CAS Number

2162149-24-6
分子量

368.902
分子式

C19H29ClN2O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 170 mg/mL (460.83 mM)
SMILES

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化学全称

(S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2-carboxamide hydrochloride

1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.

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