Digitoxin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Digitoxin 是一种有效的 Na+/K+-ATPase 抑制剂，Digitoxin 的 EC50 值为 0.78μM。

Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78μM.

Cell Viability Assay Cell Line:MHCC97H, A549, HCT116 and HeLa cells Concentration:4-1000 nMIncubation Time:24 h, 48 hResult:Dcreased the viability of these cancer cells in a dose- and time-dependent manner, with the IC50 values ranging from 0.075 to 0.395 μM following digitoxin treatment for 24 h and from 0.028 to 0.077 μM following digitoxin treatment for 48 h.Cell Cycle AnalysisCell Line:HeLa cells Concentration:4 nM, 20 nM, 100 nM Incubation Time:24 h, 36 h, 48 h Result:Increased cell population in the G2/M phase from 16.27 to 18.36, 23.46 and 31.51% at concentrations of 20 nM for12, 24 and 36 h.Increased average cell population in the G2/M phase from 16.27 to 28.07% at concentrations of 4, 20 and 100 nM for 24 h.Significantly decreased the protein expression levels of total CDK1 and phosphorylated CDK1.Apoptosis Analysis Cell Line:HeLa cells Concentration: 20 nM, 100 nM, 500 nM Incubation Time:48 h Result:Upregulated Bax expression and unaltered Bcl-2 expression.Significantly increased the expression of cytochrome c.

Animal Model:nude mice harboring HeLa tumor xenografts Dosage:1 mg/kg, 2 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Decreased the tumor volume from 330.71±45.61 to 214.56.93±73.25 mm.Strongly increased the protein levels of cleaved caspase-3.Reduced the number of Ki-67-positive cells.Animal Model:cotton rats Dosage:0.3 μg/kg, 1 μg/kg, 3 μg/kg Administration:Intraperitoneal injection (i.p.)Result:Blocked cytokine storm.Differentially affected cytokine expression.

Digitoxin | EPA Pesticide Chemical Code 097002 | NSC7529 | Carditalin

Others

Other Targets

organic anion transporter

Cardiovascular Disease

——

71-63-6

764.94

C41H64O13

>98% (HPLC)

Water: 3.9 mg/l

C[C@@H]1[C@@H](O)[C@@H](O)C[C@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](C)O[C@@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5CC[C@@]7(C)[C@]6(O)CC[C@@H]7C8=CC(OC8)=O)C4)C[C@@H]3O)C[C@@H]2O)O1

4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one

(-20℃)

With Ice Pack

≥ 2 years