KEA1-97

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KEA1-97 (KEA 1-97) 是一种小分子，可破坏硫氧还蛋白与 caspase 3 的相互作用。

KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3; activates caspases, and induces apoptosis without affecting thioredoxin activity, impairs triple-negative breast cancer cell survival; impairs in vivo breast tumor xenograft growth.

KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3.KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation.KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death.KEA1-97 (231MFP cells) resistants to survival and proliferation impairments.Western Blot Analysis Cell Line:231MFP cells Concentration:100 μM Incubation Time: Result:Impaired thioredoxin pulldown of caspase 3.Cell Proliferation Assay Cell Line:231MFP cells Concentration:10 μM Incubation Time:48 h Result:Impaired 231MFP serum-free cell proliferation.Apoptosis Analysis Cell Line:231MFP cells Concentration:10 μM Incubation Time:0~12 h Result:Activated caspase 3/7 and induced apoptotic cell death.

KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth. Animal Model:Immune-deficient SCID mice Dosage:5 mg/kg Administration:I.p.; 50 days Result:Attenuated tumor xenograft growth.

KEA 1-97

Apoptosis

Caspase

Caspase

——

——

2138882-71-8

335.163

C15H9Cl2FN4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (298.36 mM)

ClC1=NC(Cl)=NC(NC2=CC=C(C3=CC=C(F)C=C3)C=C2)=N1

4,6-dichloro-N-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine

(-20℃)

With Ice Pack

≥ 2 years