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OBE022
CAS No. 2005486-32-6
OBE022 ( OBE 022 | OBE-022 )
产品货号. M13129 CAS No. 2005486-32-6
OBE022 是一种有效的、高选择性的、口服活性的收缩性 PGF2α 前列腺素受体拮抗剂，Kb 为 5.9 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥11904 | 有现货 |
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| 50MG | ￥15624 | 有现货 |
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| 100MG | ￥19350 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称OBE022
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述OBE022 是一种有效的、高选择性的、口服活性的收缩性 PGF2α 前列腺素受体拮抗剂，Kb 为 5.9 nM。
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产品描述OBE022 is a potent, highly selective, orally active antagonist of the contractile PGF2α prostaglandin receptor with Kb of 5.9 nM, shows no activity for other human PG receptors subtypes; inhibits spontaneous, oxytocin- and PGF2α-induced human myometrial contractions alone and is more effective in combination with atosiban or nifedipine; reduces spontaneous contractions in near-term pregnant rat, OBE022 delayed RU486-induced parturition and exerted synergistic effects in combination with nifedipine; exhibits potent tocolytic effects on human tissues ex vivo and animal models in vivo without causing the adverse fetal side effects.Other Indication Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词OBE 022 | OBE-022
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通路GPCR/G Protein
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靶点Prostaglandin Receptor
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受体Prostaglandin Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number2005486-32-6
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分子量636.194
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分子式C30H35ClFN3O5S2
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纯度>98% (HPLC)
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溶解度——
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SMILESN[C@@H](C(C)C)C(OCC[C@H](NC([C@@H]1SCCN1S(=O)(C2=CC=C(C3=CC=CC=C3)C=C2)=O)=O)C4=CC=C(F)C=C4)=O
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化学全称(S)-2-Amino-3-methyl-butyric acid (S)-3-{[(S)-3-(biphenyl-4-sulfonyl)-thiazolidine-2-carbonyl]-amino}-3-(4-fluoro-phenyl)-propyl ester hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pohl O, et al. J Pharmacol Exp Ther. 2018 May 18. pii: jpet.118.247668.
2. Pohl O, et al. Br J Clin Pharmacol. 2018 Apr 30. doi: 10.1111/bcp.13622.
