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Alvimopan dihydrate
CAS No. 170098-38-1
Alvimopan dihydrate ( Alvimopan Dihydrate | Entereg | Alvimopan hydrate | LY 246736 dihydrate )
产品货号. M12598 CAS No. 170098-38-1
一种选择性外周作用的 μ-阿片类拮抗剂，IC50 为 1.7 nM，用于治疗术后肠梗阻；防止静脉注射吗啡的胃肠道反应而不影响镇痛；口服活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥472 | 有现货 |
|
| 5MG | ￥894 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Alvimopan dihydrate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种选择性外周作用的 μ-阿片类拮抗剂，IC50 为 1.7 nM，用于治疗术后肠梗阻；防止静脉注射吗啡的胃肠道反应而不影响镇痛；口服活性。
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产品描述A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved.
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体外实验Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.
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体内实验Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
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同义词Alvimopan Dihydrate | Entereg | Alvimopan hydrate | LY 246736 dihydrate
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体Opioid Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number170098-38-1
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分子量460.5631
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分子式C25H36N2O6
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(O)CNC([C@@H](CC1=CC=CC=C1)CN2C[C@H](C)[C@](C)(C3=CC=CC(O)=C3)CC2)=O.[H]O[H].[H]O[H]
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化学全称Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:2)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.
2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.
3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.
