UCB9608 ( UCB 9608 | UCB9608 )

产品货号. M12362 CAS No. 1616413-96-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

UCB9608
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

UCB9608 (UCB-9608) 是一种有效的、选择性的、口服生物可利用的 PI4KIIIβ 抑制剂，IC50 为 11 nM。
产品描述

UCB9608 (UCB-9608) is a potent, selective, orally bioavailable PI4KIIIβ inhibitor with IC50 of 11 nM; also shows an IC50 of 37 nM in the human mixed lymphocyte reaction (HuMLR) assay, only inhibits the PI4KIIIβ and PI3KC2 α, β and γ lipid kinases in apnel of 250 kinases tested at 10 uM; UCB9608 is vastly more soluble, selective compound with improved metabolic stability and excellent pharmacokinetic profile, significantly prolongs allogeneic organ engraftment in vivo.
体外实验

UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM. UCB9608 is selective for PI4KIIIβ over PI3KC2 α, β, and γ lipid kinases.UCB9608 inhibits human mixed lymphocyte reaction, the IC50 is 37 nM.
体内实验

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同义词

UCB 9608 | UCB9608
通路

PI3K/Akt/mTOR signaling
靶点

PI4K
受体

PI4K
研究领域

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适应症

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CAS Number

1616413-96-7
分子量

410.482
分子式

C20H26N8O2
纯度

>98% (HPLC)
溶解度

DMSO : 65 mg/mL 158.36 mM
SMILES

O=C(N1C[C@H](C)N(C2=C3C(N(C)N=C3)=NC(N)=N2)CC1)NC4=CC=C(OC)C=C4C
化学全称

(3S)-4-(6-amino-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide

1. Reuberson J, et al. J Med Chem. 2018 Jun 28. doi: 10.1021/acs.jmedchem.8b00521.

计算器

产品手册

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